• The potential improvement in management of patients can be e

  2019-05-07

  

  The potential improvement in management of patients can be evidenced by a paper comparing baseline symptom severity over two time frames by Khan et al.[17]. Baseline edmonton symptom assessment system (ESAS) scores reported by patients seen from 2006 to 2009 were found to exhibit significant improve

• We examined pharmacologic exposures among the subset of wome

  2019-05-07

  

  We examined pharmacologic exposures among the subset of women diagnosed with breast cancer on or after 1995 (N=620) and found that over two thirds (70.8%) received adjuvant endocrine therapy prior to hip or cytochrome p450 inhibitors fracture, including 30.8% who received tamoxifen only, 23.1% who r

• br Discussion Wellens reported an association

  2019-05-07

  

  Discussion Wellens [1] reported an association between accessory pathways characterized by anterograde decremental conduction and the description of nodoventricular connections by Mahaim [2]. Consequently, these accessory pathways were erroneously referred to as “Mahaim pathways.” McClelland et a

• Most spinal schwannomas derived from Schwann cells along

  2019-05-06

  

  Most spinal schwannomas derived from Schwann recommended reading along the dorsal sensory roots involve radicular pain as the most common initial symptom. However, symptoms may be subtle and progress slowly over time, owing to the slow-growing nature of these tumors. In our case, it\'s more difficu

• Introduction Several types of cancers including those origin

  2019-05-06

  

  Introduction Several types of cancers, including those originating in the breast, prostate, and lung, have a propensity to metastasize to the bones [1,2]. Bone metastases severely impair skeletal metabolism, and result in important clinical sequelae, such as excruciating chronic bone pain and the s

• In summary we have established an animal

  2019-05-06

  

  In summary, we have established an animal model of human NB bone metastasis in which COX-2/PGE2 plays a critical role. We provide pre-clinical data supporting the use of COX-2 inhibitors in the treatment of bone metastases in NB. Conflict of interest statement Introduction Desmoplastic fibrom

• br Discussion Metastatic RCC is

  2019-05-06

  

  Discussion Metastatic RCC is a fatal disease with survival often measured in months, rather than years. Surgery alone is the standard of care for patients who present with isolated renal disease at the time of diagnosis. However, approximately 1/3 of these patients will go on to develop clinicall

• To date over mutations in

  2019-05-06

  

  To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [

• Moving forward we identify several urgent

  2019-05-06

  

  Moving forward, we identify several urgent needs and challenges. First, the standing of p-Cresyl sulfate health workers in the health-care systems needs to be legitimised and moved away from largely grant-funded temporary employees or volunteers who might provide educational services towards skille

• br Introducci n Las encendidas palabras de fray Servando

  2019-05-06

  

  Introducción Las encendidas palabras de fray Servando Teresa de Mier provienen del Discurso preliminar que acompaña la reedición de la Brevíssima relación de la destruyción de las Indias de fray Bartolomé de las Casas, publicado en México en 1812. Fray Servando no duda en calificar al dominico, l

• Ante estas opiniones hay que tomar en cuenta que

  2019-05-06

  

  Ante estas opiniones, hay que tomar en cuenta que: “investigaciones recientes muestran que los pueblos indígenas han emergido junto norepinephrine bitartrate procesos de revitalización étnica y cultural, que han transformado el escenario sociopolítico y han puesto en tela de juicio las antiguas conc

• SGC707 This time last year to

  2019-05-06

  

  This time last year, to coincide with (March 9), launched a to highlight the rising burden of kidney disease and to encourage research partnerships to address gaps in knowledge and care, including the affordability of such care. Nephrology research and collaboration has come a relatively long way

• Bacterial LPS stimulates monocytes and tissue macrophages

  2019-05-06

  

  Bacterial LPS stimulates monocytes and tissue macrophages to release TNF-α and IL-1, which then stimulate secondary response cytokines, including IL-6. In addition to hematopoietic cells, IL-6 is synthesized by many different types of nonhematopoietic cells, including endothelium, lasting for an ext

• Leong et al reported a similar case

  2019-05-06

  

  Leong et al. reported a similar case of a short circuit in the Riata 1570 defibrillator lead, which manifested as unsuccessful defibrillation [10]. In this case, product analysis of generator indicated structural device damage owing to a short circuit in the defibrillation lead. Marenco et al. also

• 5z cost As Table shows all guidelines recommend OACs for pat

  2019-05-06

  

  As Table 2 shows, all guidelines recommend OACs for patients with a CHADS2 score of ≥2, whereas recommendations for low-risk patients with a CHADS2 score of 0/1 differ slightly across guidelines. Evidence indicating that novel OACs decrease the risk of ICH by half as compared with warfarin has affec

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