• Several questions remain to be addressed The hormones and me

  2020-12-04

  

  Several questions remain to be addressed. The hormones and metabolites that modulate expression of EERγ in the steps leading to maturation need to be identified to learn more about physiological and pathophysiological regulation of EERγ in β cells. Considering that ERRγ repressed cell cycle genes in

• Recent studies have shown that

  2020-12-04

  

  Recent studies have shown that the extracellular regulated protein kinase 1 and 2 (ERK1 and ERK2), commonly referred to collectively as ERK 1/2, are members of the mitogen-activated protein kinase (MAPK) family. This family of kinases transport signals from the surface of the cell to the nucleus, th

• The T cell receptor TCR pathway is associated

  2020-12-04

  

  The T cell receptor (TCR) pathway is associated with T cell activation and differentiation. When specific antigen peptides are recognized by the TCR, lymphocyte-specific protein tyrosine kinase (lck) phosphorylates the immune-receptor tyrosine-based activation motifs (ITAMs) of the TCR-CD3 complex a

• Our results indirectly support the

  2020-12-04

  

  Our results indirectly support the combination of resveratrol and hesperatin treatment for PDN, as this induces GLO1 activity in patients (Xue et al., 2016), as well as metformin, an FDA-approved anti-diabetic treatment, which acts as an MG scavenger to reduce MG levels in type 2 diabetic patients (

• br Conflict of interest statement br References and recommen

  2020-12-04

  

  Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We acknowledge financial support by the Swiss State Secretariat for Education, Research and Innovation (Federal

• Phenolic compounds generated during biomass pretreatment inh

  2020-12-04

  

  Phenolic compounds generated during Iberin pretreatment inhibit and/or deactivate cellulolytic/hemicellulolytic enzymes as well as the viability and fermentative capacity of yeast and bacteria [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]. Phenolic compounds cause changes in protein conformat

• Early VL diagnosis makes it possible

  2020-12-04

  

  Early VL diagnosis makes it possible to formulate a quicker and more effective treatment against the disease, which could increase the possibility of a cure for the patients, as well as reduce the toxicity of the drugs (Coelho et al., 2009); however, conventional and molecular parasitological method

• br Conclusions br Acknowledgements Implantable Microsystems

  2020-12-04

  

  Conclusions Acknowledgements Implantable Microsystems for Personalised Anti-Cancer Therapy is a EPSRC (Engineering and Physical Sciences Research Council, UK) funded grant (Ref. EP/K034510/1) Introduction Flemingia philippinensis, belonging to the legume family, is a polyphenol rich plant

• Bcl functions as a transcription repressor via

  2020-12-04

  

  Bcl6 functions as a transcription repressor via its N-terminal BTB domain and middle “second repression,” or “RD2” domain (Chang et al., 1996, Seyfert et al., 1996). A loss of function of the BCL6 BTB domain markedly impairs survival and proliferation of mature GC Caspase-8, human recombinant protei

• br Methods br Results br Discussion Skin biopsy and

  2020-12-03

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific Sulfamethazine australia organs (Donadio et al., 2005, Donadio et al., 2012a, Do

• Both meiotic COs and NCOs require DNA

  2020-12-03

  

  Both meiotic COs and NCOs require DNA synthesis, current data from sequencing also suggest that COs require more DNA synthesis than NCO 63., 64., 65.. However, analysis of the role of DNA synthesis in NCOs remains relatively uncharacterized. Emerging evidence points to a role for either Polδ or Polε

• For reductive amination by L

  2020-12-03

  

  For reductive amination by L-AmDH, the term related to the enzyme-ammonia complex is excluded rather than the enzyme-pentanone term (Table 1). If this were an ordered mechanism, this would imply ammonia binds second, after NADH and before 2-pentanone. However, a large KM,NH4 value renders ammonia bi

• Some mechanistic experiments performed in the

  2020-12-03

  

  Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects in the world from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apoptosis. This evide

• RNA sequencing RNA seq is a particularly effective technolog

  2020-12-03

  

  RNA-sequencing (RNA-seq) is a particularly effective technology for gene discovery in a given process, especially in non-model species for which reference genome sequences are not available. Although the major application of RNA-seq analyses is the identification of differentially expressed genes (D

• To further determine the cell

  2020-12-03

  

  To further determine the cell death, the autotaxin inhibitor in flasks were harvested after OGD or LTD4 treatment, washed twice with PBS, and evaluated with Annexin V (AV)-FITC apoptosis detection kit I (BD Biosciences Pharmingen, USA) on a flow cytometer (FACSCalibur, Becton–Dickinson, USA). Brief

15434 records 731/1029 page Previous Next First page 上5页 731732733734735 下5页 Last page