• In order to determine whether NF

  2021-10-12

  

  In order to determine whether NF-κB could interact with GSTP1-1 promoter, we performed EMSA. One NF-κB like (−98κB) binding site was previously described in the GSTP1-1 promoter as a regulator element. However, few data about this site have been published and its role in the GSTP1-1 gene regulation

• It has been found that WHI P a JAK

  2021-10-12

  

  It has been found that WHI-P131, a JAK3 inhibitor, induced apoptosis of CD4+ T SRT 1720 (Cetkovic-Cvrlje et al., 2012). Also, other JAK3 inhibitors (AG490 and WHI-P154) caused apoptosis in anaplastic large cell lymphoma (Amin et al., 2003). Taking into account the proapoptotic action of JAK inhibit

• The precise mechanisms of action

  2021-10-12

  

  The precise mechanisms of action of 4-PBA are as yet ambiguous. Its capacity as a chemical chaperone has been thoroughly documented for the ABC transporter family in particular (Prulière-Escabasse et al., 2007; Iram and Cole, 2014; Gordo-Gilart et al., 2016; Pomozi et al., 2017). 4-PBA has been clas

• In this study we examined whether zebrafish

  2021-10-12

  

  In this study, we examined whether zebrafish ionocytes might also share other types of similarity in transport function with kidney cells. In addition to ion transport, mammalian kidney ascorbic acid receptor also play key roles in xenobiotic elimination, through the action of ATP-Binding Cassette

• The third generation cephalosporin antibiotics can cross the

  2021-10-12

  

  The third-generation cephalosporin DPQ can cross the blood brain barrier (BBB) [94]. In addition, several studies have shown that CEF can also cross the BBB [95,96] through a facilitated transport process [95]. However, due to the fact that CEF has poor bioavailability when taken orally, CEF must b

• In fact changes in mitochondrial dynamics

  2021-10-11

  

  In fact, changes in mitochondrial dynamics directly affects many things including cellular metabolism [127], mitochondrial mass and turnover [128], mitochondrial transport, and calcium buffering [129]. Nigrostriatal DA neurons seem to have a preferential susceptibility to loss of Mfn2 when compared

• Polymerisation of HbS initiates the

  2021-10-11

  

  Polymerisation of HbS initiates the clinical complications of SCD (Bunn and Forget, 1986). The resulting sequelae are multiple and diverse, and their individual impact on pathogenesis is difficult to elucidate. Early changes include altered red cell membrane permeability (Gibson and Ellory, 2002, Le

• To ensure the induction of CYP enzymes by several inducers

  2021-10-11

  

  To ensure the induction of CYP enzymes by several inducers, specific monooxygenase activities of variously induced, uninduced and pooled liver microsomes were compared (Fig. 3). Although 3-MC, phenobarbital, acetone, and dexamethasone could induce CYP1A-, CYP2B-, CYP2E1-, and CYP3A-selective enzyme

• uPAR promotes cell associated proteolysis by

  2021-10-11

  

  uPAR promotes cell-associated proteolysis by binding to uPA which locally converts plasminogen into active plasmin [10]. Ligand-engaged uPAR also acts as a potent regulator of cell migration and matrix attachment. Being a membrane receptor, uPAR needs to interact with extracellular matrix (ECM) prot

• Macroautophagy hereafter referred to as autophagy

  2021-10-11

  

  Macroautophagy (hereafter referred to as autophagy) depends on an intracellular lysosome-dependent degradation system that maintains cellular metabolism and homeostasis [11]. Genes involved in these processes are termed autophagy-related genes (ATGs), which regulate autophagosome formation and compl

• br Application of TIRFM to visualizing

  2021-10-11

  

  Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin Chlorpropamide (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as mast cell of mutant

• The nuclear repressor BACH is known

  2021-10-11

  

  The nuclear repressor BACH1 is known to control HO-1 expression together with the transcriptional activator NRF2. The results of our study show that HO-1 gene expression in LPS-stimulated macrophages is primarily regulated via BACH1. This idea is supported by a series of experimental evidence demons

• br Direct effect of HDACs on

  2021-10-11

  

  Direct effect of HDACs on contractile function by deacetylating cytoskeletal and contractile proteins Role of HDACs in electropathology by transcriptional reprogramming Next to deacetylation of α-tubulin by HDAC6 in experimental and human AF, there is also evidence for transcriptional reprogra

• Our data demonstrate that cobas HCV s performance characteri

  2021-10-11

  

  Our data demonstrate that cobas HCV’s performance characteristics meet these requirements, making the assay useful in the management of therapy for chronic hepatitis C. We documented that cobas HCV has the requisite LOD, measureable range (15 − 1.0E + 08 IU/mL) and precision allowing for baseline HC

• Earlier we have shown relationship between cytotoxicity

  2021-10-11

  

  Earlier, we have shown relationship between cytotoxicity and receptor degeneration in Angiotensin 1/2 (1-5) receptor having specific neurotransmitter receptors (Siddiqui et al., 2008). In the present study, exposure to 4-HNE reduced expression of DA-D2 receptors in PC12 cells which was found to be

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