• The mitogen activated protein kinase MAPK

  2019-10-05

  

  The mitogen-activated protein kinase (MAPK) family, which consists of extracellular signal-regulated protein kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun N-terminal kinase (JNK), is involved in the development of NP (Hung et al., 2012, Ji et al., 2009). Recently, Zhuang et al. (2005) demonstrated that t

• br Conflict of interest statement br Acknowledgement The res

  2019-10-05

  

  Conflict of interest statement Acknowledgement The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 278742 (Eurosarc) Introduction Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like

• br User knowledge representation Various representation appr

  2019-10-04

  

  User knowledge representation Various representation approaches of user interests and preferences are proposed. In this work, we advocate a multidimensional semantic approach based on Bouzghoub et al. meta-model (Bouzeghoub and Kostadinov, 2005), depicted in Fig. 6, to model the user profile. The

• Benidipine HCl br Chk and Chk mediated signaling act as a

  2019-10-04

  

  Chk 1 and Chk 2 mediated signaling act as a barrier to tumorigenesis It was hypothesized recently that early events during tumorigenesis, such as the overexpression of oncogenes, lead to a DNA-damage response which, in turn halts tumor progression [44], [45], [46]. The DNA-damage response is prop

• Introduction Enzymes have higher selectivity specificity

  2019-10-04

  

  Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2]. A high efficient biocatalyst for industrial applications must be s

• In the present study real time polymerase chain

  2019-10-04

  

  In the present study, real-time polymerase chain reaction also confirmed that gene expressions of RT1 class II, locus Bb (RT1-Bb) was up-regulated and Spi-B transcription factor (Spib) was downregulated at day 3 after the VMH lesions. These two genes work as one of immune responses. RT1-Bb controls

• Because EBI is expressed on the

  2019-10-04

  

  Because EBI2 is expressed on the major subsets of immune cells, and small molecule antagonists for EBI2 were recently described (Benned-Jensen et al., 2013, Gessier et al., 2014), EBI2 constitutes a tempting drug target reminiscent of the sphingosine-1-phosphate receptor superagonist fingolimod/Gile

• BI-9564 kinase A different example of substrate dependent ac

  2019-10-03

  

  A different example of substrate-dependent activation is seen in CSN5, a JAMM-type DUB found in the eight subunit COP9 signalosome (CSN) [34]. The CSN deconjugates NEDD8 (neural precursor cell expressed developmentally downregulated 8) from Cullin Ring ubiquitin E3 ligases (CRLs). Through this activ

• The sixth affected individual individual is a

  2019-10-03

  

  The sixth affected individual (individual 6) is a 35-year-old female who presented with a complex combination of congenital and acquired symptoms. She was born to healthy, unrelated parents with an unremarkable family history, apart from the presence of polycystic kidney disease in her father and pa

• Muscle Ring Fingers MuRFs comprising

  2019-10-02

  

  Muscle Ring Fingers (MuRFs) comprising TRIM63 (MuRF1), TRIM55 (MuRF2) and TRIM54 (MuRF3) are the most studied TRIMs in the heart. However, with increasing knowledge of E3 ligases and recent advancements in the field, many other TRIMs such as TRIM8, TRIM21, TRIM24, TRIM32, TRIM45, TRIM69 and TRIM72 w

• To determine direct DDR binding partners and to further

  2019-10-02

  

  To determine direct DDR1-binding partners and to further connect to Akt and mTOR signaling, we performed mass spectrometry on DDR1 immunoprecipitates and found various candidates of the Akt and mTOR pathway such as LARP1 (La-related protein 1) and RPS6 (40S ribosomal protein S6/ S6). Most intriguing

• Interestingly selective ETA blockade increased cutaneous

  2019-10-02

  

  Interestingly, selective ETA blockade increased cutaneous blood flow as measured by laser Doppler fluxmetry. This is a measure of total blood flow in the different vessels in the skin including venules, TAK-715 as well as arterioles. This finding is in accordance with the previous demonstration tha

• ATP binding cassette transporters such as ABCA and ABCG are

  2019-10-02

  

  ATP-binding cassette transporters such as ABCA1 and ABCG1 are expressed on cell membranes to transport cholesterol from CC-223 to HDL. These transporters help to improve RCT and reduce atherosclerosis. ABCA1 and ABCG1 gene expression are primarily induced by the stimulation of liver X receptor/reti

• br Protein protein interactions of LEI L DNase II and

  2019-10-02

  

  Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino Penicillin G Sodium substitution in the RSL can led to the inhibition of a totally different p

• br Acknowledgments br Multicellular organisms respond rapidl

  2019-10-01

  

  Acknowledgments Multicellular organisms respond rapidly, and adapt to cellular stress to maximize cell survival. The cellular stress response, also called (ISR), is universally conserved and independent of the stressor. ISR induces rapid, transient reprogramming of cellular protein translation

14730 records 891/982 page Previous Next First page 上5页 891892893894895 下5页 Last page