• br Manganese based imaging probes br Imaging

  2021-10-08

  

  Manganese-based imaging probes Imaging of vesicular monoamine transporter 2 (VMAT2) Imaging of sulfonylurea receptor 1 (SUR1) In mammals, insulin secretion is mediated by the membrane potential of pancreatic β-cells. Increases in glucose levels lead to blocking of ATP-sensitive potassium ch

• br GPR is a class A GPCR

  2021-10-08

  

  GPR119 is a class A GPCR expressed on pancreatic β-cells and certain enteroendocrine Zinc Pyrithione which upon activation with an agonist, increases insulin secretion in response to rising glucose levels. Mechanistically, this insulinotropic effect is bifurcated involving both GPR119-mediated β-

• Accumulating studies revealed a decline of

  2021-10-08

  

  Accumulating studies revealed a decline of TET1 expression in various cancers including breast, liver, colon, skin, prostate cancers [[36], [37], [38]]. Contrast to these studies, our previous research shows that TET1 is overexpressed in EC and improves the efficacy of chemotherapy in EC, coincide w

• br Ca influx through glutamate receptors is thought to play

  2021-10-08

  

  Ca2+ influx through glutamate receptors is thought to play a critical role in synaptogenesis and in the formation of neuronal circuitry during early development[45]. Because AMPA receptors might contribute to these processes, particularly at times and in cells in which NMDA receptor expression is

• Transient forebrain ischemia in rodents induces a

  2021-10-08

  

  Transient forebrain ischemia in rodents induces a reduction in expression of mRNA encoding the AMPA receptor subunit GluR265, 66, 67, 68, 69 (Fig. 3). gluR2 mRNA expression is markedly reduced in the CA1 region (the Cefepime Dihydrochloride Monohydrate region most vulnerable to ischemia-induced dam

• As our earlier study investigated glut

  2021-10-08

  

  As our earlier study investigated glut mRNA levels in response to a protein load contained in a meal and the studies that used glucose and insulin injections did not examine GLUT expression, this study sought to investigate the effects of hyperglycaemia and insulin on mRNA levels in the spiny dogfis

• Epinephrine responses to hypoglycemia are probably triggered

  2021-10-08

  

  Epinephrine responses to hypoglycemia are probably triggered centrally, perhaps with input from peripheral hypoglycemia sensing [3], [4]. We observed increased epinephrine responses in GCK-MODY and I366F diabetic mice. Consistent with a role for Lithium Citrate GCK in detecting a low blood glucose,

• br Conclusion br Conflict of

  2021-10-08

  

  Conclusion Conflict-of-Interest JJH has collaborated with several different pharmaceutical companies during the last 30 years; is currently receiving speaker honoraria from NovoNordisk and MSD and is on advisory boards for NovoNordisk. The author is currently supported by an independent grant

• Extending time action is another strategy

  2021-10-08

  

  Extending time action is another strategy to increase in vivo efficacy. Twice daily administration of the unacylated analogs herein caused greater body weight loss in DIO mice than the equivalent dose administered as a single daily injection, suggesting that protracted time action should yield more

• br Introduction Calorie restriction CR in the absence of mal

  2021-10-08

  

  Introduction Calorie restriction (CR), in the absence of malnutrition, has beneficial effects on CGK733 function, including reducing the incidence of age-related neurodegenerative disease (Gräff et al., 2013), eliciting anti-depressant behavior (Lutter et al., 2008) and improving memory function

• Sperm capacitation was negatively r p related with

  2021-10-07

  

  Sperm capacitation was negatively (r = −0.68; p  The correlation of FAAH expression with bull conception rate was positive but not significant (r = 0.22). No significant relationship was observed between the expression levels of either CB1 receptor or FAAH and any of the sperm quality parameters stu

• Following the discovery of diketo compounds S and L

  2021-10-07

  

  Following the discovery of β-diketo compounds S-1360 [31] and L-731988 [32] as anti-HIV integrase inhibitors, a group of researchers discovered a potent Ticlopidine HCl receptor based derivative (1) as the inhibitor of HIV integrase functioning at the 3′-processing and strand transfer steps of HIV

• br Discussion Our results showed that the histamine

  2021-10-07

  

  Discussion Our results showed that the histamine H1 receptor antagonist/inverse agonists, pyrilamine and cetirizine, attenuated not only NMDAR-mediated synaptic current but also LTP in Shaffer collateral-CA1 pyramidal neuron synapses. The H1 receptor antagonist/inverse agonist-induced attenuation

• br Results br Discussion Our current study demonstrates that

  2021-10-07

  

  Results Discussion Our current study demonstrates that the sustained activation of Yap overrides the p27-mediated checkpoint, at least in part, through the degradation of FoxO family proteins, allowing polyploid cells to proliferate inappropriately with mitotic defects and resulting in centros

• Heme activates the master regulator

  2021-10-07

  

  Heme activates the master regulator of the anti-oxidant stress response, NRF2, which mediates the up-regulation of a battery of phase II detoxifying genes [106]. Remarkably, HO-1 induction by NRF2 is regulated via an interplay with the transcriptional repressor BACH1 at the Maf recognition pde-5 inh

15486 records 558/1033 page Previous Next First page 上5页 556557558559560 下5页 Last page